Drª Lucymara Fassarella Agnez-Lima

Drª Lucymara Fassarella Agnez-Lima

Departamento de Biologia Celular e Genética

Possui graduação em Ciências Biológicas pela Universidade Federal do Espírito Santo (1991), mestrado (1994) e doutorado em Ciências Biológicas (Biologia/Genética) pela Universidade de São Paulo (1998) e pós-doutorado pela Universitat de Barcelona (2010). Atualmente é professora titular livre da Universidade Federal do Rio Grande do Norte, orientadora permanente nos cursos de pós-graduação em Bioquímica (UFRN), RENORBIO (doutorado vinculado a Rede Nordeste de Biotecnologia - Multinstitucional) e Bioinformática (UFRN). Foi coordenadora do programa de pós-graduação em Genética e Biologia Molecular da UFRN (2005-2008), vice coordenadora do programa de pós-graduação RENORBIO ? Nucleadora UFRN (2008-2012) e coordenadora geral do programa RENORBIO (2017-2021). Foi membro da diretoria da Sociedade Brasileira de Genética (SBG) (2010-2012 e 2014-2016), da diretoria da SBG Regional NE (2016-2018) e da Sociedade Brasileira de Mutagênese, Carcinogênnese e Teratogênese Ambiental (2001-2005). Participou da comissão de avaliação de programas de pós-graduação da CAPES pela área de Ciências Biológicas I (trienal 2013 e quadrienal 2017). Participou da comissão julgadora do prêmio CAPES de teses, área Ciências Biológicas I (2014, 2015, 2016 e 2018). Foi editora associada da BMC genomics (2013-2018) e da Biotechnology Research & Innovation (2017 a 2020). Atualmente é review editor do jornal Frontiers in Microbiology. Foi representante do Centro de Biociências no Conselho de Ensino Pesquisa e Extensão da UFRN (2015-2017). Atualmente é representante do Centro de Biociências no Núcleo de Petróleo e Gás (2015 a atual) e no conselho administrativo da FUNPEC (2021-atual). É membro do conselho deliberativo da incubadora de empresas BioInova do Centro de Biociências da UFRN. É cofundadora da startup MicroCiclo Biotecnoloigia LTDA, em incubação na incubadora BioInova (UFRN). Tem experiência na área de Genética, atuando principalmente nos seguintes temas: reparo de DNA, mutagênese, estresse oxidativo, genética humana, genômica, genética de microorganismos, metagenômica, degradação de petróleo, biossurfactantes e biorremediação.

Produção bibliográfica

  1. DA FONSÊCA, MARBELLA MARIA BERNARDES ; FREITAS, JÚLIA FIRME ; SILVA-PORTELA, RITA DE CÁSSIA BARRETO ; MINNICELLI, CAROLINA FONSECA ; DA SILVA-BARBALHO, KAMILLA KARLA ; Agnez-Lima, Lucymara Fassarella . First insights into bacterial communities in pre-salt oil reveal a far-from-sterile environment. FUEL, v. 312, p. 122860, 2022.
  2. OLIVEIRA, THAIS TEIXEIRA ; COUTINHO, Leonam Gomes ; DE OLIVEIRA, LAYSA OHANA ALVES ; TIMOTEO, Ana Rafaela de Souza ; FARIAS, GUILHERME CAVALCANTI ; Agnez-Lima, Lucymara Fassarella . APE1/Ref-1 Role in Inflammation and Immune Response. Frontiers in Immunology, v. 13, p. 1-15, 2022.
  3. DE MELO CAMPOS, JULLIANE TAMARA ARAÚJO ; DE MEDEIROS, JORGE LUIZ DANTAS ; DE MELO, MARIA EDUARDA CARDOSO ; DA SILVA, MONIQUE ALVARES ; DE OLIVEIRA, MATHEUS SENA ; SARMENTO, AQUILES SALES CRAVEIRO ; Lima, Lucymara Fassarella Agnez ; DE FREITAS FREGONEZI, GUILHERME AUGUSTO ; LIMA, JOSIVAN GOMES . Endoplasmic reticulum stress and muscle dysfunction in congenital Lipodystrophies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 3, p. 166120, 2021.
  4. SOARES, PAULO EDUARDO T. ; DANTAS, MÁRCIA DANIELLE A. ; SILVA-PORTELA, RITA DE CÁSSIA B. ; Agnez-Lima, Lucymara F. ; LANZA, DANIEL CARLOS F. . Characterization of Penaeus vannamei mitogenome focusing on genetic diversity. PLoS One, v. 16, p. e0255291, 2021.
  5. OLIVEIRA, THAIS TEIXEIRA ; FONTES-DANTAS, FABRÍCIA LIMA ; DE MEDEIROS OLIVEIRA, RAYSSA KARLA ; PINHEIRO, DANIELE MARIA LOPES ; COUTINHO, Leonam Gomes ; DA SILVA, VANDECLECIO LIRA ; DE SOUZA, SANDRO JOSÉ ; Agnez-Lima, Lucymara Fassarella . Chemical Inhibition of Apurinic-Apyrimidinic Endonuclease 1 Redox and DNA Repair Functions Affects the Inflammatory Response via Different but Overlapping Mechanisms. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, p. 1, 2021.
  6. LAMARCA, ALESSANDRA P. ; DE ALMEIDA, LUIZ G. P. ; FRANCISCO, RONALDO DA SILVA ; Lima, Lucymara Fassarella Agnez ; SCORTECCI, Kátia Castanho ; PEREZ, VINÍCIUS PIETTA ; BRUSTOLINI, OTAVIO J. ; SOUSA, EDUARDO SÉRGIO SOARES ; SECCO, DANIELLE ANGST ; SANTOS, ANGELA MARIA GUIMARÃES ; ALBUQUERQUE, GEORGE REGO ; MARIANO, ANA PAULA MELO ; MACIEL, BIANCA MENDES ; GERBER, ALEXANDRA L. ; GUIMARÃES, ANA PAULA DE C. ; NASCIMENTO, PAULO RICARDO ; NETO, FRANCISCO PAULO FREIRE ; GADELHA, SANDRA ROCHA ; PORTO, LUÍS CRISTÓVÃO ; CAMPANA, ELOIZA HELENA ; JERONIMO, SELMA MARIA BEZERRA ; VASCONCELOS, ANA TEREZA R. . Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P.1 lineage and diversification within P.2 clade in Brazil. PLoS Neglected Tropical Diseases, v. 15, p. e0009835, 2021.
  7. DE LIMA, DANIEL CHAVES ; MEDEIROS, INÁCIO GOMES ; DE CÁSSIA SILVA-PORTELA, RITA ; DA SILVA JUNIOR, FRANCISCO CARLOS ; FASSARELA AGNEZ-LIMA, LUCYMARA ; DE SOUZA, JORGE ESTEFANO SANTANA ; BATISTUZZO DE MEDEIROS, SILVIA R. . Identification of plasmids from Brazilian Chromobacterium violaceum strains. CANADIAN JOURNAL OF MICROBIOLOGY, v. Nov 15, p. 1-10, 2021.
  8. ALOISE, Débora de Almeida ; COURA-VITAL, WENDEL ; CARNEIRO, MARIÂNGELA ; RODRIGUES, MARLUS VENÂNCIO ; TOSCANO, GISLANI ACÁSIA DA SILVA ; DA SILVA, RAMIZA BERNARDINO ; SILVA-PORTELA, RITA DE CÁSSIA BARRETO ; FONTES-DANTAS, FABRÍCIA LIMA ; Agnez-Lima, Lucymara Fassarella ; VITOR, RICARDO WAGNER ALMEIDA ; ANDRADE-NETO, VALTER FERREIRA DE . Association between ocular toxoplasmosis and APEX1 and MYD88 polymorphism. ACTA TROPICA, v. 221, p. 106006, 2021.
  9. ARAUJO, S. C. S. ; SILVA-PORTELA, RITA C. B. ; LIMA, D. C. ; DA FONSECA, MARBELLA MARIA BERNARDES ; ARAUJO, W. ; SILVA, U. B. ; NAPP, AMANDA P. ; PEREIRA, JOSÉ EVANDRO S. ; VAINSTEIN, M. H. ; AGNEZ-LIMA, L. F. . MBSP1: a biosurfactant protein derived from a metagenomic library with activity in oil degradation.. Scientific Reports, v. 10, p. 1340, 2020.
  10. SARMENTO, AQUILES SALES CRAVEIRO ; LIMA, JOSIVAN GOMES ; DE SOUZA TIMOTEO, ANA RAFAELA ; URURAHY, MARCELA ABBOTT GALVÃO ; DE ARAÚJO, AURIGENA ANTUNES ; VASCONCELOS, ROSEANE CARVALHO ; DANTAS, VERÔNICA KRISTINA CÂNDIDO ; Agnez-Lima, Lucymara Fassarella ; DE MELO CAMPOS, JULLIANE TAMARA ARAÚJO . Changes in redox and endoplasmic reticulum homeostasis are related to congenital generalized lipodystrophy type 2. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1865, p. 158610, 2020.
  11. SARMENTO, AQUILES SALES CRAVEIRO ; LIMA, JOSIVAN GOMES ; DE SOUZA TIMOTEO, ANA RAFAELA ; URURAHY, MARCELA ABBOTT GALVÃO ; DE ARAÚJO, AURIGENA ANTUNES ; VASCONCELOS, ROSEANE CARVALHO ; DANTAS, VERÔNICA KRISTINA CÂNDIDO ; Agnez-Lima, Lucymara Fassarella ; DE MELO CAMPOS, JULLIANE TAMARA ARAÚJO . Changes in redox and endoplasmic reticulum homeostasis are related to congenital generalized lipodystrophy type 2. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1865, p. 158610, 2020.
  12. DA FONSECA, MARBELLA MARIA BERNARDES ; MINNICELLI, CAROLINA FONSECA ; SILVA-PORTELA, RITA DE CÁSSIA BARRETO ; DE FARIAS, MIRNA FERREIRA ; DOS SANTOS, PAULA RAFAELA SILVA ; FERNANDES, GLAUBER JOSÉ TUROLLA ; Agnez-Lima, Lucymara Fassarella . Unlocking and functional profiling of the bacterial communities in diesel tanks upon additive treatment. FUEL, v. 236, p. 1311-1320, 2019.
  13. CRAVEIRO SARMENTO, AQUILES SALES ; FERREIRA, LEONARDO CAPISTRANO ; LIMA, JOSIVAN GOMES ; DE AZEVEDO MEDEIROS, LÁZARO BATISTA ; BARBOSA CUNHA, PATRÍCIA TAINÁ ; Agnez-Lima, Lucymara Fassarella ; GALVÃO URURAHY, MARCELA ABBOTT ; DE MELO CAMPOS, JULLIANE TAMARA ARAÚJO . The worldwide mutational landscape of Berardinelli-Seip congenital lipodystrophy. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, v. 781, p. 30-52, 2019.
  14. NAPP, AMANDA P. ; PEREIRA, JOSÉ EVANDRO S. ; OLIVEIRA, JORGE S. ; SILVA-PORTELA, RITA C.B. ; AGNEZ-SILVA, LUCYMARA F. ; PERALBA, MARIA C.R. ; BENTO, FÁTIMA M. ; PASSAGLIA, LUCIANE M.P. ; THOMPSON, CLAUDIA E. ; VAINSTEIN, MARILENE H. . Comparative metagenomics reveals different hydrocarbon degradative abilities from enriched oil-drilling waste. CHEMOSPHERE, v. 209, p. 7-16, 2018.
  15. NAPP, AMANDA P. ; PEREIRA, JOSÉ EVANDRO S. ; OLIVEIRA, JORGE S. ; SILVA-PORTELA, RITA C.B. ; AGNEZ-SILVA, LUCYMARA F. ; PERALBA, MARIA C.R. ; BENTO, FÁTIMA M. ; PASSAGLIA, LUCIANE M.P. ; THOMPSON, CLAUDIA E. ; VAINSTEIN, MARILENE H. . Comparative metagenomics reveals different hydrocarbon degradative abilities from enriched oil-drilling waste. CHEMOSPHERE, v. 209, p. 7-16, 2018.
  16. DE SOUZA TIMOTEO, ANA RAFAELA ; GONÇALVES, ANA ÉLIDA MENEZES MAGALHÃES ; SALES, LUCAS AMADEUS PORPINO ; ALBUQUERQUE, BETINA MENEZES ; DE SOUZA, JORGE ESTEFANO SANTANA ; DE MOURA, PATRÍCIA CRISTINA PASCOTO ; DE AQUINO, MARCOS ALBERTO ARRUDA ; Agnez-Lima, Lucymara Fassarela ; LAJUS, TIRZAH BRAZ PETTA . A portrait of germline mutation in Brazilian at-risk for hereditary breast cancer. BREAST CANCER RESEARCH AND TREATMENT, v. 172, p. 1-10, 2018.
  17. CRAVEIRO SARMENTO, AQUILES SALES ; DE AZEVEDO MEDEIROS, LÁZARO BATISTA ; Agnez-Lima, Lucymara Fassarella ; LIMA, JOSIVAN GOMES ; DE MELO CAMPOS, JULLIANE TAMARA ARAÚJO . Exploring Seipin: From Biochemistry to Bioinformatics Predictions. INTERNATIONAL JOURNAL OF CELL BIOLOGY, v. 2018, p. 1-21, 2018.
  18. ANDRADE NETO, N F ; TAVARES, M T S ; FERREIRA, E A C ; SALES, A I L ; LIMA, L F A ; LONGO, E ; BOMIO, M R D ; MOTTA, F V . Photoluminescent and antimicrobial properties of silver doped indium hydroxide synthesized by one-step microwave-assisted hydrothermal method. International Journal of Applied Ceramic Technology, v. 2018, p. 1-10, 2018.
  19. PINHEIRO, DANIELE MARIA LOPES ; DE OLIVEIRA, ANA HELENA SALES ; COUTINHO, Leonam Gomes ; FONTES, FABRÍCIA LIMA ; DE MEDEIROS OLIVEIRA, RAYSSA KARLA ; OLIVEIRA, THAIS TEIXEIRA ; FAUSTINO, ANDRÉ LUÍS FONSECA ; LIRA, VANDECLÉCIO ; DE MELO CAMPOS, JULLIANE TAMARA ARAÚJO ; LAJUS, TIRZAH BRAZ PETTA ; DE SOUZA, SANDRO JOSÉ ; Agnez-Lima, Lucymara Fassarella . Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation. FREE RADICAL BIOLOGY AND MEDICINE, v. 130, p. 8-22, 2018.
  20. OLIVEIRA, JORGE S. ; ARAÚJO, WYDEMBERG J. ; FIGUEIREDO, RICARDO M. ; SILVA-PORTELA, RITA C. B. ; DE BRITO GUERRA, ALAINE ; DA SILVA ARAÚJO, SINARA CARLA ; MINNICELLI, CAROLINA ; CARLOS, ALINE CARDOSO ; DE VASCONCELOS, ANA TEREZA RIBEIRO ; FREITAS, ANA TERESA ; Agnez-Lima, Lucymara F. . Biogeographical distribution analysis of hydrocarbon degrading and biosurfactant producing genes suggests that near-equatorial biomes have higher abundance of genes with potential for bioremediation. BMC MICROBIOLOGY, v. 17, p. 168, 2017.
  21. DE AZEVEDO MEDEIROS, LÁZARO BATISTA ; CÂNDIDO DANTAS, VERÔNICA KRISTINA ; CRAVEIRO SARMENTO, AQUILES SALES ; Agnez-Lima, Lucymara Fassarella ; MEIRELES, ADRIANA LÚCIA ; XAVIER NOBRE, THAIZA TEIXEIRA ; DE LIMA, JOSIVAN GOMES ; DE MELO CAMPOS, JULLIANE TAMARA ARAÚJO . High prevalence of Berardinelli-Seip Congenital Lipodystrophy in Rio Grande do Norte State, Northeast Brazil. Diabetology & Metabolic Syndrome, v. 9, p. 80, 2017.
  22. COUTINHO, LEONAM G. ; DE OLIVEIRA, ANA HELENA SALES ; WITWER, MATTHIAS ; LEIB, Stephen L. ; Agnez-Lima, Lucymara F. . DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6. Journal of Neuroinflammation, v. 14, p. 243, 2017.
  23. DANTAS, MÁRCIA DANIELLE A. ; TEIXEIRA, DIEGO G. ; SILVA-PORTELA, RITA CÁSSIA B. ; SOARES, PAULO EDUARDO T. ; LIMA, JOÃO PAULO M.S. ; Agnez-Lima, Lucymara F. ; LANZA, DANIEL CARLOS F. . Direct sequencing of the white spot syndrome virus from Brazil: genome assembly and new insights on phylogeny. VIRUS RESEARCH, v. 245, p. 52-61, 2017.
  24. Melo, Julliane T.A. ; TIMOTEO, Ana Rafaela de Souza ; LAJUS TBP ; BRANDÃO JA ; Souza-Pinto, NC ; MENCK, C. F. M. ; CAMPALANS, A. ; RADICELLA, J. P. ; VESSONI, A. T. ; MUOTRI, A. R. ; Agnez-Lima, Lucymara Fassarella . XPC deficiency is related to APE1 and OGG1 expression and functions. Mutation Research (Print), v. 784, p. 00-00, 2016.
  25. SILVA, Rita de Cássia Barreto da ; CARVALHO, Fabíola Marques de ; PEREIRA, C. P. M. ; Souza-Pinto, NC ; MODESTI, M. ; FUCHS, R. P. P. ; Agnez-Lima, Lucymara Fassarella . ExoMeg1: a new exonuclease from metagenomic library. Scientific Reports, v. 6, p. 19712, 2016.
  26. VESSONI, A. T. ; HERAI, R. H. ; KARPIAK, J. V. ; LEAL, Angélica Maria de Sousa ; TRUJILLO, C. A. ; QUINET, A. ; AGNEZ-LIMA, LUCYMARA F ; Menck, Carlos F.M. ; MUOTRI, A. R. . Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony. Human Molecular Genetics (Print), v. 2016, p. ddw008, 2016.
  27. TAVARES, TALLITA CRUZ LOPES ; NORMANDO, LEONARDO RIBEIRO OLIVEIRA ; DE VASCONCELOS, ANA TEREZA RIBEIRO ; GERBER, ALEXANDRA LEHMKUHL ; Agnez-Lima, Lucymara Fassarella ; MELO, VÂNIA MARIA MACIEL . Metagenomic analysis of sediments under seaports influence in the Equatorial Atlantic Ocean. Science of the Total Environment, v. 557-558, p. 888-900, 2016.
  28. LEAL, Angélica Maria de Sousa ; DE QUEIROZ, JANA DARA FREIRES ; DE MEDEIROS, SILVIA REGINA BATISTUZZO ; LIMA, TATJANA KEESEN DE SOUZA ; Agnez-Lima, Lucymara Fassarella . Violacein induces cell death by triggering mitochondrial membrane hyperpolarization in vitro. BMC Microbiology (Online), v. 15, p. 115, 2015.
  29. NOGUEIRA, VANESSA L.R. ; ROCHA, LIDIANNE L. ; COLARES, GEÓRGIA B. ; ANGELIM, ALYSSON LIRA ; NORMANDO, LEONARDO O.R. ; CANTÃO, MAURÍCIO E. ; Agnez-Lima, Lucymara F. ; ANDREOTE, FERNANDO DINI ; MELO, VÂNIA M.M. . Microbiomes and potential metabolic pathways of pristine and anthropized Brazilian mangroves. Regional Studies in Marine Science, v. 1, p. 1-7, 2015.
  30. MARCELINO, HENRIQUE ; DA SILVA, ACARÍLIA ; GOMES, MONIQUE ; OLIVEIRA, ELQUIO ; NAGASHIMA-JUNIOR, TOSHIYUKI ; PINHEIRO, GARDÊNIA ; DA SILVA, ACARÍZIA ; TIMOTEO, ANA ; Agnez-Lima, Lucymara ; AYALA, ALEJANDRO ; OLIVEIRA, ANSELMO ; EGITO, ERYVALDO . Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles. Polymers, v. 7, p. 2304-2315, 2015.
  31. LOPES PINHEIRO, DANIELE MARIA ; FONTES, FABRICIA LIMA ; DE OLIVEIRA, ANA HELENA SALES ; COUTINHO, Leonam Gomes ; da Silva, Thayse Azevedo ; LEIB, STEPHEN L ; LIMA LF, AGNEZ . Polymorphisms in DNA Repair Gene XRCC1 (Arg194Trp) and (Arg399Gln) and their Role in the susceptibility of Bacterial Meningitis. Journal of Meningitis, v. 01, p. 105, 2015.
  32. QUEIROZ, JANA DARA FREIRES DE ; LEAL, Angélica Maria de Sousa ; TERADA, MAYSA ; Agnez-Lima, Lucymara Fassarela ; COSTA, ISOLDA ; PINTO, NADJA CRISTHINA DE SOUZA ; BATISTUZZO DE MEDEIROS, SILVIA REGINA . Surface modification by argon plasma treatment improves antioxidant defense ability of CHO-k1 cells on titanium surfaces. Toxicology in Vitro, v. 28, p. 381-387, 2014.
  33. OLIVEIRA, Ana Helena Sales de ; SILVA, ACARÍZIA EDUARDO DA ; OLIVEIRA, IURI MARQUES DE ; HENRIQUES, João Antônio Pegas ; Agnez-Lima, Lucymara Fassarella . MutY-Glycosylase: an overview on mutagenesis and activities beyond the GO system. Mutation Research (Print), v. 769, p. 119-131, 2014.
  34. COUTINHO, Leonam Gomes ; CHRISTEN, S. ; BELLAC, C. L. ; Fontes FL ; SOUZA, Fladjule Rejane Soares de ; GRANDGIRARD, D. ; LEIB, Stephen L. ; Agnez-Lima, Lucymara Fassarella . The kynurenine pathway is involved in bacterial meningitis. Journal of Neuroinflammation, v. 11, p. 169, 2014.
  35. FONTES, FABRÍCIA LIMA ; PINHEIRO, DANIELE MARIA LOPES ; OLIVEIRA, Ana Helena Sales de ; OLIVEIRA, RAYSSA KARLA DE MEDEIROS ; LAJUS, TIRZAH BRAZ PETTA ; Agnez-Lima, Lucymara Fassarella . Role of DNA repair in host immune response and inflammation. Mutation Research. Reviews in Mutation Research (Print), v. 763, p. 246-257, 2014.
  36. PACCHIONI, RALFO G. ; CARVALHO, FABÍOLA M. ; THOMPSON, CLAUDIA E. ; FAUSTINO, ANDRÉ L. F. ; NICOLINI, FERNANDA ; PEREIRA, TATIANA S. ; SILVA, RITA C. B. ; CANTÃO, MAURICIO E. ; GERBER, ALEXANDRA ; VASCONCELOS, ANA T. R. ; Agnez-Lima, Lucymara F. . Taxonomic and functional profiles of soil samples from Atlantic forest and Caatinga biomes in northeastern Brazil. MICROBIOLOGYOPEN, v. 3, p. n/a-n/a, 2014.
  37. SILVA, G. K. ; Melo, Julliane T.A. ; OLIVEIRA, Ana Helena Sales de ; SILVA, E. C. ; Batistuzzo de Medeiros, S. R. ; AGNEZ, L. F. ; AGNEZ-LIMA, L. F. . O julgamento da mutação. Genética na Escola, v. 1, p. 42-57, 2013.
  38. COUTINHO, LEONAM G ; GRANDGIRARD, DENIS ; LEIB, STEPHEN L ; AGNEZ-LIMA, LUCYMARA F . Cerebrospinal-fluid cytokine and chemokine profile in patients with pneumococcal and meningococcal meningitis. BMC Infectious Diseases (Online), v. 13, p. 326, 2013.
  39. MARINOTTI, O. CERQUEIRA, G. C. DE ALMEIDA, L. G. P. FERRO, M. I. T. LORETO, E. L. D. S. ZAHA, A. TEIXEIRA, S. M. R. WESPISER, A. R. ALMEIDA E SILVA, A. SCHLINDWEIN, A. D. PACHECO, A. C. L. SILVA, A. L. D. C. D. GRAVELEY, B. R. WALENZ, B. P. LIMA, B. D. A. RIBEIRO, C. A. G. NUNES-SILVA, C. G. DE CARVALHO, C. R. SOARES, C. M. D. A. DE MENEZES, C. B. A. MATIOLLI, C. CAFFREY, D. ARAUJO, D. A. M. DE OLIVEIRA, D. M. GOLENBOCK, D. , et al. ; The Genome of Anopheles darlingi, the main neotropical malaria vector. Nucleic Acids Research, v. 41, p. 7387-7400, 2013.
  40. MAIRA, N. ; TORRES, T. M. ; DE OLIVEIRA, A. L. ; DE MEDEIROS, S. R. B. ; AGNEZ-LIMA, L. F. ; LIMA, J. P. M. S. ; SCORTECCI, K. C. . Identification, characterisation and molecular modelling of two AP endonucleases from base excision repair pathway in sugarcane provide insights on the early evolution of green plants. Plant Biology (Stuttgart), v. 16, p. n/a-n/a, 2013.
  41. FELIPE, MARIA BEATRIZ M.C. ; DE CARVALHO, FABÍOLA M. ; FÉLIX-SILVA, JULIANA ; FERNANDES-PEDROSA, MATHEUS F. ; SCORTECCI, KÁTIA C. ; Agnez-Lima, Lucymara F. ; BATISTUZZO DE MEDEIROS, SÍLVIA R. . Evaluation of genotoxic and antioxidant activity of an Aesculus hippocastanum L. (Sapindaceae) phytotherapeutic agent. Biomedicine & Preventive Nutrition, v. 3, p. 261-266, 2013.
  42. Nascimento MS ; MAGALHAES, J. E. M. ; PINHEIRO, T. S. ; AZEVEDO, A. K. N. ; COUTINHO, Leonam Gomes ; BASEIA, I. G. ; AGNEZ-LIMA, L. F. ; Leite E.L. . Polysaccharides from the fungus Scleroderma nitidum with anti-infl ammatory potential modulate cytokine levels and the expression of Nuclear Factor kB. Revista Brasileira de Farmacognosia (Impresso), v. 22, p. 60-68, 2012.
  43. Schuch, André Passaglia ; Yagura, Teiti ; Makita, Kazuo ; Yamamoto, Hiromasa ; Schuch, Nelson Jorge ; Agnez-Lima, Lucymara Fassarella ; MacMahon, Ricardo Monreal ; Menck, Carlos Frederico Martins . DNA damage profiles induced by sunlight at different latitudes. Environmental and Molecular Mutagenesis (Print), v. 53, p. 198-206, 2012.
  44. ALMEIDA, D. D. ; SCORTECCI, Kátia Castanho ; JUNQUEIRA-DE-AZEVEDO, I. L. M. ; Agnez-Lima, Lucymara Fassarella ; Batistuzzo de Medeiros, S. R. ; KOBASHI, L. S. ; SILVA-JUNIOR, A. A. ; FERNANDES-PEDROSA, M. F. . Profiling the resting venom gland of the scorpion Tityus stigmurus through a transcriptomic survey. BMC Genomics, v. 13, p. 362, 2012.
  45. Agnez-Lima, Lucymara F.; Melo, Julliane T.A. ; Silva, Acarí ; Oliveira, Ana Helena S. ; Timoteo, Ana Rafaela S. ; Lima-Bessa, Keronninn M. ; Martinez, Glaucia R. ; Medeiros, Marisa H.G. ; Di Mascio, Paolo ; Galhardo, Rodrigo S. ; Menck, Carlos F.M. . DNA damage by singlet oxygen and cellular protective mechanisms. Mutation Research. Reviews in Mutation Research (Print), v. 751, p. 15-28, 2012.
  46. Silva-Fernandes, Isabelle Joyce de Lima ; da Silva, Thayse Azevedo ; Agnez-Lima, Lucymara Fassarella ; Ferreira, Márcia Valéria Pitombeira ; Rabenhorst, Silvia Helena Barem . Helicobacter pylori genotype and polymorphisms in DNA repair enzymes: Where do they correlate in gastric cancer?. Journal of Surgical Oncology (Print), v. 106, p. 448-455, 2012.
  47. SILVA, ANDRÉ LEANDRO ; ALEXANDRINO, FRANCISCO ; VERISSIMO, LOURENA MAFRA ; Agnez-Lima, Lucymara Fassarella ; EGITO, Lucila Carmem Monte ; DE OLIVEIRA, ANSELMO GOMES ; DO EGITO, ERYVALDO SOCRATES TABOSA . Physical Factors Affecting Plasmid DNA Compaction in Stearylamine-Containing Nanoemulsions Intended for Gene Delivery. Pharmaceuticals, v. 5, p. 643-654, 2012.
  48. SOUZA, Fladjule Rejane Soares de ; Fontes FL ; SILVA, Thayse A ; COUTINHO, Leonam Gomes ; LEIB, Stephen L. ; AGNEZ-LIMA, L. F. . Association of kynurenine aminotransferase II gene C401T polymorphism with markers of immune response in patients with meningitis.. BMC Medical Genetics (Online), v. 12, p. 51-00, 2011.
  49. da Silva, Thayse Azevedo ; FONTES, FABRÍCIA LIMA ; COUTINHO, Leonam Gomes ; DE SOUZA, FLADJULE REJANE SOARES ; DE MELO, JULLIANE TAMARA ARAÚJO ; DE SOUTO, JANEUSA TRINDADE ; LEIB, Stephen L. ; Agnez-Lima, Lucymara Fassarella . SNPs in DNA repair genes associated to meningitis and host immune response. Mutation Research (Print), v. 713, p. 39-47, 2011.
  50. BARBOSA, Jefferson da S ; CABRAL, Thiago M ; FERREIRA, D. N. ; AGNEZ-LIMA, L. F. ; Batistuzzo de Medeiros, S. R. . Genotoxicity Assessment In Aquatic Environment Impacted By The Presence Of Heavy Metals.. Ecotoxicology and Environmental Safety, v. 73, p. 320-325, 2010.
  51. EGITO, Lucila C. Monte ; SANTOS, Patrícia Estevam dos ; AMARAL, V. S. ; Batistuzzo de Medeiros, S. R. ; AGNEZ-LIMA, L. F. . Use of native species Crenicichla menezesi (Ariidae) as a model for in situ evaluation of genotoxicity in surface water.. Science of the Total Environment, v. 408, p. 6042-6046, 2010.
  52. VERÍSSIMO, Lourena Mafra ; AGNEZ-LIMA, L. F. ; EGITO, Lucila C. Monte ; Oliveira A G ; Tabosa do Egito, E. S. . PHARMACEUTICAL EMULSIONS: A NEW APPROACH FOR GENE THERAPY.. Journal of Drug Targeting (Print), v. 18, p. 333-342, 2010.
  53. QUEIROZ, L. S. ; NASCIMENTOA, M. S. ; CRUZ, A. K. M. ; CASTRO, A. J. G. ; MOURA, M. F. V. ; BASEIA, I. G. ; ARAUJO, R. M. ; AGNEZ-LIMA, L. F. ; Leite E.L. . Glucans from the Caripia. montagnei mushroom present anti-inflammatory activity.. International Immunopharmacology (Print), v. 10, p. 34-42, 2010.
  54. Silva, W A ; Pinheiro, A M ; COUTINHO, Leonam Gomes ; MARINHO, Luiz Alberto ; AGNEZ-LIMA, L. F. . Epidemiological Profile of Acute Bacterial Meningitis in the State of Rio Grande do Norte, Brazil. Revista da Sociedade Brasileira de Medicina Tropical (Impresso), v. 43, p. 455-457, 2010.
  55. Marcon, Alexandre Endres ; Ferreira, Douglisnilson de Morais ; Moura, Maria de Fátima Vitória de ; Campos, Thomas Ferreira da Costa ; Amaral, Viviane Souza do ; AGNEZ-LIMA, L. F. ; Batistuzzo de Medeiros, Sílvia Regina . Genotoxic analysis in aquatic environment under influence of cyanobacteria, metal and radioactivity. Chemosphere (Oxford), v. 81, p. 773-780, 2010.
  56. SANTOS, Patrícia Estevam dos ; EGITO, Lucila Carmem Monte ; Batistuzzo de Medeiros, S. R. ; AGNEZ-LIMA, L. F. . Genotoxicity induced by Eugenia caryophyllata infusion. Journal of Toxicology and Environmental Health. Part A, v. 71, p. 439-444, 2008.
  57. EGITO, Lucila Carmem Monte ; MEDEIROS, Maria das Graças ; MEDEIROS, Silvia Regina Batistuzzo de ; AGNEZ-LIMA, L. F. . Cytotoxic and Genotoxic Potential of Surface Water from Pitimbu River, Northeast Brazil.. Genetics and Molecular Biology, v. 30, p. 435-441, 2007.
  58. FONSÊCA, Marbella Maria Bernardes da ; ALARCON, Frank J. B. ; VASCONSELOS, Ana Tereza de ; AGNEZ-LIMA, L. F. . A model to RecA protein from Mycoplasma synoviae. Genetics and Molecular Biology, v. 30, p. 290-295, 2007.
  59. BARCA, F. N. T. V. ; AGNEZ-LIMA, L. F. ; Batistuzzo de Medeiros, S. R. . BASE EXCISION REPAIR PATHWAY IS INVOLVED IN THE REPAIR OF LESIONS GENERATED BY FLAVONOID-ENRICHED FRACTIONS OF PEPPER TREE (Schinus terebinthifolius, Raddi) STEM BARK. Environmental and Molecular Mutagenesis (Print), v. 48, p. 672-681, 2007.
  60. SCORTECCI, Kátia Castanho ; LIMA, Alexsandra F O ; CARVALHO, Fabíola Marques de ; SILVA, Uaska Bezerra e ; AGNEZ-LIMA, L. F. ; Batistuzzo de Medeiros, S. R. . A characterization of a MutM/Fpg ortholog in sugarcane ? a monocot plant. Biochemical and Biophysical Research Communications (Print), v. 361, p. 1054-1060, 2007.
  61. CARVALHO, Fabíola Marques de ; FONSECA, Marbela Maria Bernardes da ; MEDEIROS, Sílvia Regina Batistuzzo de ; SCORTECCI, Kátia Castanho ; BLAHA, Carlos Alfredo Galindo ; AGNEZ-LIMA, L. F. . DNA repair in reduced genome: the Mycoplasma model. Gene (Amsterdam), USA, v. 260, p. 111-119, 2005.
  62. VASCONSELLOS, Ana Tereza de ; CONSORTION, Brasilian Nacional Genome Project ; PROGRAM, Southern Genome Investigation ; AGNEZ-LIMA, L. F. . Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae. Journal of Bacteriology (Print), v. 187, n.16, p. 5568-5577, 2005.
  63. MONTEIRO, Meika Iwata ; SOUTO, Marcilio C P de ; GONÇALVES, Luiz Marcos G ; AGNEZ-LIMA, L. F. . Machine learning techniques for predicting Bacillus subtilies promoters. Lecture Notes in Computer Science, Belin, v. 3594, p. 77-84, 2005.
  64. DUARTE, F. T. ; CARVALHO, Fabíola Marques de ; SILVA, Uaska Bezerra e ; SCORTECCI, Kátia Castanho ; BLAHA, Carlos Alfredo Galindo ; AGNEZ-LIMA, L. F. ; MEDEIROS, Silvia Regina Batistuzzo de . DNA repair in Chromobacterium violaceum. Genetics and Molecular Research, v. 3, n.1, p. 167-180, 2004.
  65. PETTA, T. B. ; MEDEIROS, Silvia Regina Batistuzzo de ; EGITO, Eryvaldo Socrates Tabosa Do ; AGNEZ-LIMA, L. F. . Genotoxicity induced by saponified coconut oil surfactant in prokaryote systems. Mutagenesis, Inglaterra, v. 19, n.6, p. 441-444, 2004.
  66. MARQUES, R. C. P. ; MEDEIROS, Silvia Regina Batistuzzo de ; LACERDA, C. D. G. ; BARBOSA FILHO, J. M. ; AGNEZ-LIMA, L. F. . Evaluation of mutagenic potential of yangambin and hydroalcoolic extract from Ocotea duckei by Ames test.. Mutation Research. Genetic Toxicology and Environmental Mutagenesis, Amsterdan, v. 536, p. 117-120, 2003.
  67. CARVALHO, M. C. R. D. ; BARCA, F. N. T. V. ; AGNEZ-LIMA, L. F. ; MEDEIROS, Silvia Regina Batistuzzo de . Evaluation of mutagenic activity of the bark decoction of pepper tree (Schinus terebinthifolius Raddi). Environmental and Molecular Mutagenesis (Print), New York, v. 42, n.3, p. 185-191, 2003.
  68. VASCONCELOS, Ana Tereza Ribeiro de ; AGNEZ-LIMA, L. F. ; CONSORTION, Brasilian Nacional Genome Project . The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability. Proceedings of the National Academy of Sciences of the United States of America, Washington, v. 100, n.20, p. 11660-11665, 2003.
  69. CAVALCANTE, ANA KARINA DIAS ; MARTINEZ, GLAUCIA REGINA ; Di Mascio, Paolo ; Menck, Carlos Frederico Martins ; Agnez-Lima, Lucymara Fassarella . Cytotoxicity and mutagenesis induced by singlet oxygen in wild type and DNA repair deficient Escherichia coli strains. DNA Repair (Print), v. 1, p. 1051-1056, 2002.
  70. AGNEZ-LIMA, L. F.; NAPOLITANO, R. L. ; FUCHS, R. P. P. ; Di MACIO, P. ; MUOTRI, A. R. ; MENCK, C. F. M. . DNA repair and sequence context affect 1O2- induced mutagenesis in bacteria. Nucleic Acids Research, Oxford, v. 29, n.13, p. 2899-2903, 2001.
  71. AGNEZ-LIMA, L. F.; Di MASCIO, P. ; DEMPLE, B. ; MENCK, C. F. M. . Singlet molecular oxygen triggers the soxRS regulon of Escherichia coli. Biological Chemistry (Print), Berlin, v. 382, p. 1071-1075, 2001.
  72. AGNEZ-LIMA, L. F.; MEDEIROS, Silvia Regina Batistuzzo de ; MAGGI, B. S. ; QUARESMA, G. A. S. . Base excision repair in sugarcane. Genetics and Molecular Biology, Ribeirão Preto, v. 24, n.1-4, p. 123-129, 2001.
  73. AGNEZ-LIMA, L. F.; Di MASCIO, P. ; NAPOLITANO, R. L. ; FUCHS, R. P. P. ; MENCK, C. F. M. . Mutation Spectrum Induced by Singlet Oxygen in Escherichia coli Deficient in Exonuclease III. Photochemistry and Photobiology, v. 70, n.4, p. 505-511, 1999.
  74. AGNEZ-LIMA, L. F.; COSTA de OLIVEIRA, R. L. ; Di MASCIO, P. ; MENCK, C. F. M. . Involviment of Escherichia coli Exonuclease III and Endonuclease IV in the Repair of Singlet Oxygen-Induced DNA Damage. Carcinogenesis (New York. Print), v. 17, n.5, p. 1183-1185, 1996.
  75. MENCK, C. F. M. ; Di MASCIO, P. ; AGNEZ-LIMA, L. F. ; RIBEIRO, D. T. ; COSTA de OLIVEIRA, R. L. . Genetic Deleterious Effects of Singlet Oxygen. Química Nova (Impresso), Brasil, v. 16, n.4, p. 328-336, 1993.